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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM2
All Species:
25.45
Human Site:
Y125
Identified Species:
40
UniProt:
P31350
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31350
NP_001025.1
389
44878
Y125
S
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100144
351
40744
E109
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
Dog
Lupus familis
XP_540076
394
45449
Y130
S
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
Cat
Felis silvestris
Mouse
Mus musculus
P11157
390
45077
H126
A
L
K
P
D
E
R
H
F
I
S
H
V
L
A
Rat
Rattus norvegicus
Q4KLN6
390
45020
H126
A
L
K
P
D
E
R
H
F
I
S
H
V
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506085
394
45462
Y130
S
L
K
P
E
E
K
Y
F
I
S
H
V
L
A
Chicken
Gallus gallus
XP_419948
384
44421
Y120
S
L
K
P
E
E
K
Y
F
I
S
H
V
L
A
Frog
Xenopus laevis
NP_001080772
386
44577
Y122
S
L
K
T
D
E
R
Y
F
I
S
H
V
L
A
Zebra Danio
Brachydanio rerio
P79733
386
44575
Y122
S
L
K
D
E
E
R
Y
F
I
S
H
V
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48592
393
45096
H129
R
L
K
D
D
E
R
H
F
I
S
H
V
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42170
381
44271
Y117
K
M
N
G
D
E
Q
Y
F
I
S
R
I
L
A
Sea Urchin
Strong. purpuratus
XP_780110
412
47263
H143
N
L
K
D
E
E
R
H
F
I
S
H
V
L
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q6Y657
333
38312
V91
S
T
R
F
M
S
D
V
Q
I
S
E
A
R
A
Baker's Yeast
Sacchar. cerevisiae
P09938
399
46129
F132
R
M
N
E
N
E
R
F
F
I
S
R
V
L
A
Red Bread Mold
Neurospora crassa
Q9C167
410
46679
F133
R
L
N
D
D
E
K
F
F
I
S
H
I
L
A
Conservation
Percent
Protein Identity:
100
N.A.
72.4
95.4
N.A.
91.2
89.7
N.A.
90.6
88.4
84
83.5
N.A.
68.9
N.A.
59.9
67.9
Protein Similarity:
100
N.A.
82
96.4
N.A.
95.3
94.6
N.A.
95.4
94
91
90.7
N.A.
79.3
N.A.
74.8
77.6
P-Site Identity:
100
N.A.
6.6
100
N.A.
80
80
N.A.
93.3
93.3
86.6
93.3
N.A.
73.3
N.A.
46.6
80
P-Site Similarity:
100
N.A.
20
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
86.6
N.A.
73.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.8
58.4
64.3
Protein Similarity:
N.A.
N.A.
N.A.
69.9
71.4
75.8
P-Site Identity:
N.A.
N.A.
N.A.
26.6
53.3
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
66.6
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
0
0
0
0
0
0
0
0
0
7
0
94
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
27
40
0
7
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
14
40
87
0
7
0
0
0
7
7
0
0
% E
% Phe:
0
0
0
7
0
0
0
14
87
7
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
27
0
0
0
74
0
0
0
% H
% Ile:
7
0
0
0
0
0
0
0
0
94
0
0
14
0
0
% I
% Lys:
7
0
67
0
0
0
20
0
0
0
0
0
0
0
0
% K
% Leu:
0
74
0
0
0
7
0
0
0
0
0
0
0
87
0
% L
% Met:
0
14
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
27
0
14
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
40
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
7
0
0
7
0
0
7
% Q
% Arg:
20
0
7
0
0
0
60
0
7
0
0
14
0
7
0
% R
% Ser:
47
0
0
0
0
7
0
0
0
0
100
0
0
0
0
% S
% Thr:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
0
0
0
0
7
7
0
0
0
0
74
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _